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KMID : 1123920080220051276
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 5 p.1276 ~ p.1282
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Effects of OnDam-TanghapChongMyoung-Tang and DoDam-TanghapChongMyoung-Tang on Protecting Microglia and Inhibiting Acetylcholinesterase and Oxidants
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Cheong Myung-Hee
Jung In-Chul
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Abstract
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This experiment was designed to investigate the effect of the ODTCMT and DDTCMT extract on protecting microglia and inhibiting acetylcholinesterase and oxidants. The effects of the ODTCMT and DDTCMT extract on cell death of BV2 microglial cell line treated by ; expression of NO, ROS in BV2 microglial cell line treated by lipopolysaccharide (LPS) ; AChE activity in PC-12 cell treated by NGF were investigated, respectively. The ODTCMT and DDTCMT extract significantly increased cell viability in BV2 microglial cell line treated with . The ODTCMT and DDTCMT extract suppressed the NO and RDS production in BV2 microglial cell line treated by LPS. The ODTCMT and DDTCMT extract groups also showed inhibition of AChE activity in PC-12 cell line. According to the above result, it is suggested that the ODTCMT and DDTCMT extract might be usefully applied for prevention and treatment of Alzheimer’s disease. OnDam-TanghapChongMyoung-Tang (ODTCMT), DoDam-TanghapChongMyoung-Tang (DDTCMT), Microglia, acetylcholinesterase, ROS.
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KEYWORD
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Eight Principle Pattern Identification, Sasang typology, Greater-Lesser-Yin-Yang
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